DNA replication

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Keeping the balance: How epigenetics monitors cancer genes

The human genome contains around 20,000 genes with two copies per gene, one inherited from each parent. Changes in the genome including gene breaks, rearrangements, and extra gene copies are frequent in many diseases, most commonly in cancer. DNA breaks occur often throughout the genome,... click to read more

Zach Gray | PhD student at Cancer Epigenetics Institute, Fox Chase Cancer Center, Philadelphia PA 19111; Nuclear Dynamics and Cancer Program, Fox Chase Cancer Center, Philadelphia PA 19111; Institute for Cancer Research, Fox Chase Cancer Center, Philadelphia PA 19111

Madison Honer | PhD student at Cancer Epigenetics Institute, Fox Chase Cancer Center, Philadelphia PA 19111; Nuclear Dynamics and Cancer Program, Fox Chase Cancer Center, Philadelphia PA 19111; Institute for Cancer Research, Fox Chase Cancer Center, Philadelphia PA 19111

Johnathan Whetstine | Professor at Cancer Epigenetics Institute, Fox Chase Cancer Center, Philadelphia PA 19111

DNA

epigenetics

histones

DNA replication

Cancer biology

Reading time 4 min

published on May 13, 2024

Writing cell memory: how Histones play a role in Epigenetic Memory

Expression of a correct set of genes at the right time is crucial for cells to maintain their cell-type specific function. Epigenetic cell memory supports maintenance of such gene expression programs, with specific chromatin states regulating which genes to express or to keep silent. Chromatin... click to read more

Valentin Flury | Postdoctoral Research Fellow at University of Copenhagen

Anja Groth | Professor at University of Copenhagen

epigenetics

chromatin

histones

DNA replication

Reading time 4 min

published on Oct 4, 2023